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Topic: Genome Engineering Seminar Series at HMS

Please click the link below to join the webinar:
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US: +13017158592,,94394339529# or +13126266799,,94394339529#
Or Telephone:
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Webinar ID: 943 9433 9529
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Meeting ID: 943 9433 9529




Genome Writers Guild:

CRISPR Medicine News  

Addgene technical tips and reagents:

Educational materials at IGI:

(feel free to make suggestions to:

When is it?
-Mondays 1pm-2pm EST via zoom.
What is the format?
-Zoom webinar, 1hr meeting.
-30min each presenter (20min presentation + 10min questions).
-Group/shared presentations are still 30min total
-Attendees ask questions using the zoom Q&A function

What is the zoom link?

Who presents?
-First authors of recent (<1yr) genome engineering papers or manuscripts

Can I attend?
-Yes, anyone in the world is welcome to attend the meetings.

I'm not affiliated with Harvard Medical School, can I attend?
-Yes, anyone in the world is welcome to attend the meetings.

Do I need experience in genome engineering to attend?
-No, attendees can have any level of expertise in genome engineering (beginners are welcome).

Who attends these meetings?
-Attendees have a wide spectrum of interests, scientific backgrounds, and career positions, ranging from undergrads, technicians, grad students, post-docs, principal investigators, etc.

How can I receive announcements of upcoming speakers?
-Join our mailing list.

Are the talks recorded?
-If speakers consent, the recordings will be available as a link on our website within 1 week. See the "Past seminars" tab.

Can I share the zoom link with others?
-Yes, please distribute information about our seminar series to anyone you think is interested.

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Past Seminar Schedule

2022 Nov 28

Break-no talks


Monday, November 28, 2022, 1:00pm to 2:00pm

2022 Nov 21

Martin Pačesa and Santi Bhattarai-Kline


Monday, November 21, 2022, 1:00pm to 2:00pm

Martin Pačesa, Jinek Lab, University of Zurich

Target-induced conformational activation and mismatch tolerance of CRISPR-Cas9

Nature (2022) and Cell (2022)



Santi Bhattarai-Kline, Shipman Lab, Gladstone Institute of Data Science and Biotechnology, San Francisco.

Recording gene expression order in DNA by CRISPR addition of retron barcodes

Nature (2022)





2022 Nov 14

Break - no talks


Monday, November 14, 2022, 1:00pm to 2:00pm

2022 Nov 07

Zhixin Lei and Sung-Ik Cho


Monday, November 7, 2022, 1:00pm to 2:00pm



Zhixin Lei, Chengqi Yi Lab. Peking-Tsinghua Center for Life Sciences, Peking University.

Mitochondrial base editor induces substantial nuclear off-target mutations

Nature (2022)





Sung-Ik Cho, Kim Lab. Seoul National University, Seoul.

Targeted A-to-G base editing in human mitochondrial DNA with programmable deaminases

Cell (2022)





2022 Oct 31
2022 Oct 24

Minja Velimirovic and Chunyi Hu & Sam van Beljouw


Monday, October 24, 2022, 1:00pm to 2:00pm


Minja VelimirovicSherwood Lab, Brigham and Women's Hospital, Harvard Medical School

Peptide fusion improves prime editing efficiency

Nature Communications (2022)



      Chunyi Hu & Sam van BeljouwKe Lab. Cornell University

      Craspase is a CRISPR RNA-guided, RNA-activated protease.

      Science (2022)




2022 Oct 17

Alena Bishop and Qichen Yuan


Monday, October 17, 2022, 1:00pm to 2:00pm

       Alena Bishop, Gantz Lab. University of California San Diego

       Double-tap gene drive uses iterative genome targeting to help overcome resistance alleles

       Nature Communications (2022)



      Qichen Yuan, Gao Lab. Rice University, Houston 

      Multiplex base- and prime-editing with drive-and-process CRISPR arrays

      Nature Communications (2022)






2022 Oct 03

Eric Aird and Vivasvan S. Vykunta


Monday, October 3, 2022, 1:00pm to 2:00pm


          Eric Aird, Corn Lab, ETH Zurich

          Recursive Editing improves homology-directed repair through retargeting of undesired outcomes

          Nature Communications (2022)


          Vivasvan S. Vykunta, Marson Lab, Gladstone-UCSF Institute of Genomic Immunology.

          University of California San Francisco.  

          High-yield genome engineering in primary cells using a hybrid ssDNA repair

          template and small-molecule cocktails

          Nature Biotechnology (2022)



2022 Sep 26
2022 Sep 19
2022 Sep 12
2022 Apr 18
2022 Apr 11
2022 Apr 04
2022 Mar 28



Monday, March 28, 2022, 1:00pm to 2:00pm

2022 Mar 21
2022 Mar 07
2022 Feb 28

Courtney Carlson and Aditya Raguram and Samagya Banskota


Monday, February 28, 2022, 1:00pm to 2:00pm




Courtney Carlson, Chang Liu lab, Department of Biomedical Engineering, UC Irvine

Molecular recording of sequential cellular events into DNA, biorxiv, 2021


aditya and samagya-banskota


Aditya Raguram and Samagya Banskota, David Liu Lab, Harvard University and Broad Institute, Boston, United States. 

Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins. Cell. 2022



2022 Feb 14
2022 Feb 07
2022 Jan 24
2021 Nov 29

No seminar


Monday, November 29, 2021, 1:00pm to 2:00pm

No seminar
2021 Nov 22

Junhong Choi and Jens Magnusson


Monday, November 22, 2021, 1:00pm to 2:00pm



Junhong Choi, Shendure Lab, University of Washington, Seattle, USA.

Precise genomic deletions using paired prime editing Nature Biotechnology 2021





Jens Magnusson, Qi Lab, Standford University, USA.

Enhanced Cas12a multi-gene regulation using a CRISPR array separator. Elife 2021




2021 Nov 15

Ahsen Özcan and Peter Chen


Monday, November 15, 2021, 1:00pm to 2:00pm



Ahsen ÖzcanAbudayyeh-Gootenberg lab, McGovern Institute for Brain Research at MIT, Cambridge, MA, USA

Programmable RNA targeting with the single-protein CRISPR effector Cas7-11. Nature (2021).


peter chen


Peter Chen, Liu Lab, Harvard University and Broad Institute, Boston, United States.

Enhanced prime editing systems by manipulating cellular determinants of editing outcomes. Cell 2021





2021 Nov 08

Weiting Zhang and Doyon Kim


Monday, November 8, 2021, 1:00pm to 2:00pm

Weiting Zhang



Weiting Zhang, Yeh Lab, Massachusetts General Hospital, Boston, United States.

CRISPR prime editing with ribonucleoprotein complexes in zebrafish and primary human cells. Nature Biotechnol 2021.

Doyon Kim
Doyon Kim, Kim Lab, Genome Editing Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea

Upcoming Seminar Schedule

2022 Dec 12

Florian Schmidt, Jakob Zimmermann, Tanmay Tanna and Monica Neugebauer


Monday, December 12, 2022, 1:00pm to 2:00pm

Florian Schmidt, Jakob Zimmermann, Tanmay Tanna, Platt Lab and Macpherson Lab.  ETH Zurich and Bern University

Noninvasive assessment of gut function using transcriptional recording sentinel cells

Science (2022)


Monica Neugebauer, Liu Lab. Broad Institute of MIT and Harvard.

Evolution of an adenine base editor into a small, efficient cytosine base editor with low off-target activity

Nature Biotechnology (2022)


2022 Dec 19

Matthew Durrant, Alison Fanton, Josh Tycko and Liang Chen


Monday, December 19, 2022, 1:00pm to 2:00pm

Matthew Durrant, Alison Fanton, Hsu Lab, Arc Institute and University of California, Berkeley

Josh Tycko, Bintu Lab, Stanford University

Systematic discovery of recombinases for efficient integration of large DNA sequences into the human genome. Nature Biotechnology (2022)


Liang Chen, Dali Li Lab. School of Life Sciences, East China Normal University

Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing

Nature Biotechnology (2022)


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