Ping Xu, Wei Lab, Peking University, Beijing, China
Genome-wide interrogation of gene functions through base editor screens empowered by barcoded sgRNAs. Nat Biotechnol. 2021
Luke Koblan, Liu Lab, Broad Institute, Boston, United States
Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning. Nat Biotechnol. 2021
Julian Geilenkeuser and Dong-Jiunn Jeffery Truong (Westmeyer Lab), Technical University of Munich
Exonuclease-enhanced prime editors
Nature Methods 2024
Briana Van Treeck (Collins Lab), University of California at Berkeley
Harnessing eukaryotic retroelement proteins for transgene insertion into human safe-harbor loci
Nature Biotechnology 2024
Han Altae-Tran & Soumya Kannan (Zhang Lab), Broad Institute and MIT
Uncovering the functional diversity of rare CRISPR-Cas systems with deep terascale clustering
Science 2024
Ryan McNulty (Adamson Lab), Princeton University
Efficient prime editing in two-cell mouse embryos using PEmbryo
Nature Biotechnology 2024
Matt Durrant and Nicholas Perry (Hsu Lab), Arc Institute
Bridge RNAs direct modular and programmable recombination of target and donor DNA
Biorxiv 2024
Emma Huang (Feilong Meng Lab), University of Chinese Academy of Sciences
C-to-G editing generates double-strand breaks causing deletion, transversion and translocation
Nature Cell Biology 2024
Recording: https://harvard.zoom.us/rec/play/cC_qnlqSQClsNmCZBdXXigB2vdiVPTkc3Dg01Ow...
Liliya Mukhametzyanova (Buchholz Lab), Technical University Dresden
Activation of recombinases at specific DNA loci by zinc-finger domain insertions
Nature Biotechnology 2024
Sarah Camara-Wilpert and David Mayo-Muñoz (Redondo Lab and Fineran Lab), University of Copenhagen and University of Otago
Bacteriophages suppress CRISPR–Cas immunity using RNA-based anti-CRISPRs
Nature 2023
Ralf Schmidt and Carl Ward (Marson Lab), Gladstone-UCSF Institute of Genomic Immunology
Base-editing mutagenesis maps alleles to tune human T cell functions
Nature 2023
Zi-Xian Liu (Liu Lab) Tsinghua University
Hydrolytic endonucleolytic ribozyme (HYER) is programmable for sequence-specific DNA cleavage
Science 2024
Weimin Zhang (Boeke Lab), NYU Langone Health
Mouse genome rewriting and tailoring of three important disease loci
Nature 2023
Cian Schmitt-Ulms and Alisan Kayabolen (Abudayyeh-Gootenberg Lab), Broad Institute of MIT and Harvard
Programmable RNA writing with trans-splicing
Biorxiv 2024
Nicolas Mathis (Schwank Lab), University of Zurich
bioRxiv 2023
Elijah Mena (Elledge lab), Harvard Medical School
Defining E3 ligase–substrate relationships through multiplex CRISPR screening
Nature Cell Biology 2023
Connor Tou and Joana Ferreira da Silva (Kleinstiver Lab), Mass General Hospital (MGH), MIT and Harvard Medical School (HMS)
Click editing enables programmable genome writing using DNA polymerases and HUH endonucleases
bioRvix 2023
Barun Mahata (Hilton lab), Rice University.
Nature Methods 2023
Recording: https://harvard.zoom.us/rec/share/_aE2qk5exvp0PHmK_sZqH8szkq1rM_PsIPXPg_...
Laura Breda, Tyler Papp, and Michael Triebwasser (Hamideh Parhiz Lab), Perelman School of Medicine, University of Pennsylvania, and Children's Hospital of Philadelphia
In vivo hematopoietic stem cell modification by mRNA delivery
Science 2023
Antonio Santinha (Platt Lab), ETH Zurich
Transcriptional linkage analysis with in vivo AAV-Perturb-seq
Nature 2023
Recording: https://harvard.zoom.us/rec/share/4s_CHtPkdTFGARQipXPTKvM_ecSX23Qz5MtO5q...
Lukas Schmidheini (Schwank Lab), University of Zurich
Continuous directed evolution of a compact CjCas9 variant with broad PAM compatibility
Nature Chemical Biology 2023
Chris Hsiung (Gilbert Lab), Arc Institute
bioRxiv 2023
Dana Foss and Joseph Muldoon (Wilson Lab) University of California, Berkeley; (Eyquem Lab) University of California, San Francisco;
Peptide-mediated delivery of CRISPR enzymes for the efficient editing of primary human lymphocytes
Nature Biomedical Engineering 2023
José L. McFaline-Figueroa (McFaline-Figueroa Lab) Columbia University
Biorxiv 2023
Goosang Yu, (Hyongbum Henry Kim Lab), Yonsei University College of Medicine, Seoul 03722, Republic of Korea
Prediction of efficiencies for diverse prime editing systems in multiple cell types
Cell 2023
Martina Fiumara (Luigi Naldini Lab), San Raffaele Telethon Institute for Gene Therapy, Milan, Italy
Genotoxic effects of base and prime editing in human hematopoietic stem cells
Nature Biotechnology 2023
Stephan Riesenberg, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
Efficient high-precision homology-directed repair-dependent genome editing by HDRobust
Nature Methods 2023
Xiaoyi Li (Shendure Lab), University of Washington, Seattle, WA, USA
Chromatin context-dependent regulation and epigenetic manipulation of prime editing
bioRxiv 2023
Hongyuan Fei (Kevin Zhao, Qi Biodesign), (Gao Lab) University of Chinese Academy of Sciences, Beijing, China
Discovery of deaminase functions by structure-based protein clustering
Cell 2023
Xingjie Ren and Han Yang (Shen Lab); University of California, San Francisco
High throughput PRIME editing screens identify functional DNA variants in the human genome
bioRxiv 2023
George Lampe & Rebeca King (Sternberg Lab). Columbia University, New York
Nature Biotechnology 2023
Florence Chardon (Shendure Lab). University of Washington, Seattle,
Multiplex, single-cell CRISPRa screening for cell type specific regulatory elements
bioRxiv 2023
Kristin Knouse, Massachusetts Institute of Technology (MIT).
Genome-scale CRISPR screening in a single mouse liver
Cell Genomics 2022
Jaesuk Lee (Jin-Soo Kim Lab) Center for Genome Engineering, Institute for Basic Science, Daejeon, Republic of Korea.
Prime editing with genuine Cas9 nickases minimizes unwanted indels
Nature Communications 2023
Michael Wheeler, Brigham and Women's Hospital, Harvard Medical School, The Broad Institute
Droplet-based forward genetic screening of astrocyte–microglia cross-talk
Science 2023
Connor Tsuchida (Doudna Lab), University of California, Berkeley. Innovative Genomics Institute
Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells
bioRxiv 2023
Jing Zeng, Linda Yingqi Lin (Bauer Lab), Manuel Tognon (Giugno Lab). Boston Children's Hospital, Harvard Medical School, University Verona
Human genetic diversity alters off-target outcomes of therapeutic gene editing
Nature Genetics 2023
Qianxin Wu, Wellcome Sanger Institute
Molecular Cell 2023
Jonas Koeppel & Juliane Weller & Elin Madli Peets (Parts Group). Wellcome Sanger Institute, UK
Nature Biotechnology (2023)
Osama Abdin (Philip M. Kim Lab). University of Toronto, Canada
A universal deep-learning model for zinc finger design enables transcription factor reprogramming
Nature Biotechnology (2023)
Erman Karasu (Corn Lab). ETH Zurich
TREX1 restricts CRISPR-Cas9 genome editing in human cells
bioRxiv 2023
Shota Nakade (Timothy Lu Lab). Massachusetts Institute of Technology (MIT)
Frame Editors for Precise, Template-Free Frameshift
bioRxiv 2022
Lucie Guo, Lei (Stanley) Qi Lab. Stanford University
Multiplexed genome regulation in vivo with hyper-efficient Cas12a
Nature Cell Biology 2022
Hannah Ghasemi (Richardson Lab). UC Santa Barbara
Interstrand crosslinking of homologous repair template DNA enhances gene editing in human cells
Nature Biotechnology 2023
David Colognori (Doudna Lab). University of California, Berkeley.
Precise transcript targeting by CRISPR-Csm complexes
Nature Biotechnology 2023
Huawei Tong (Yang Lab). HuiGene Therapeutics Co. Ltd, China
High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects
Nature Biotechnology 2022
Päivi Pihlajamaa (Taipale Lab). University of Helsinki, University of Cambridge
Nature Biotechnology 2022
Alessio Nahmad (Barzel Lab) & Ella Goldschmidt (Madi Lab). Tel Aviv University
Frequent aneuploidy in primary human T cells after CRISPR–Cas9 cleavage
Nature Biotechnology 2022
