S	M	T	W	T	F	S
	1	2	3	4	5	6
7	8	9	10	11	12	13
14	15	16	17	18	19	20
21	22	23	24	25	26	27
28	29	30

2024 Apr 22

Victor Tieu and David Fiflis

Date:

Monday, April 22, 2024, 1:00pm to 2:00pm

Victor Tieu (Qi Lab and Mackall Lab). Stanford Universiry

A versatile CRISPR-Cas13d platform for multiplexed transcriptomic regulation and metabolic engineering in primary human T cells

Cell 2024

David Fiflis (Asokan Lab). Duke University

Repurposing CRISPR-Cas13 systems for robust mRNA trans-splicing

Nature Communications 2024

2024 Apr 08

Julian Geilenkeuser & Dong-Jiunn Jeffery Truong and Briana Van Treeck

Date:

Monday, April 8, 2024, 1:00pm to 2:00pm

Julian Geilenkeuser and Dong-Jiunn Jeffery Truong (Westmeyer Lab), Technical University of Munich

Exonuclease-enhanced prime editors

Nature Methods 2024

Briana Van Treeck (Collins Lab), University of California at Berkeley

Harnessing eukaryotic retroelement proteins for transgene insertion into human safe-harbor loci

Nature Biotechnology 2024

Recording: https://harvard.zoom.us/rec/share/BvRuwQugLXGY63qsYQ_yomMdI3lYGPgrcj5urRHJC8juKRDVjK8ck9MDZqjhxkcC.nZZMEJLyTD96hRgO

2024 Apr 01

Han Altae-Tran & Soumya Kannan and Ryan McNulty

Date:

Monday, April 1, 2024, 1:00pm to 2:00pm

Han Altae-Tran & Soumya Kannan (Zhang Lab), Broad Institute and MIT

Uncovering the functional diversity of rare CRISPR-Cas systems with deep terascale clustering

Science 2024

Ryan McNulty (Adamson Lab), Princeton University

Efficient prime editing in two-cell mouse embryos using PEmbryo

Nature Biotechnology 2024

Recording: https://harvard.zoom.us/rec/share/spnMtA_--Mkq38_K4iP39INLeRKhWKBmnsCh_U_O3tOtBc1u3YVwPORzQLgIIdA1.Qd1QA6oqY-2PcYFX

2024 Mar 25

Matt Durrant, Nicholas Perry and Emma Huang

Date:

Monday, March 25, 2024, 1:10pm to 2:00pm

Matt Durrant and Nicholas Perry (Hsu Lab), Arc Institute

Bridge RNAs direct modular and programmable recombination of target and donor DNA

Biorxiv 2024

Emma Huang (Feilong Meng Lab), University of Chinese Academy of Sciences

C-to-G editing generates double-strand breaks causing deletion, transversion and translocation

Nature Cell Biology 2024

Recording: https://harvard.zoom.us/rec/play/cC_qnlqSQClsNmCZBdXXigB2vdiVPTkc3Dg01Ow...

2024 Mar 11

Liliya Mukhametzyanova, Sarah Camara-Wilpert, and David Mayo-Muñoz

Date:

Monday, March 11, 2024, 1:00pm to 2:00pm

Liliya Mukhametzyanova (Buchholz Lab), Technical University Dresden

Activation of recombinases at specific DNA loci by zinc-finger domain insertions

Nature Biotechnology 2024

Sarah Camara-Wilpert and David Mayo-Muñoz (Redondo Lab and Fineran Lab), University of Copenhagen and University of Otago

Bacteriophages suppress CRISPR–Cas immunity using RNA-based anti-CRISPRs

Nature 2023

Recording: https://harvard.zoom.us/rec/share/kEJqNQAJXvNVLTK3TMbP36omnTtfoWsEHf5kqPYHyD_urgeD98Ph3w4DTS_Jm2ni.SaD9o83SMAZx6w55

2024 Mar 04

Ralf Schmidt, Carl Ward, and Zi-Xian Liu

Date:

Monday, March 4, 2024, 1:00pm to 2:00pm

Ralf Schmidt and Carl Ward (Marson Lab), Gladstone-UCSF Institute of Genomic Immunology

Base-editing mutagenesis maps alleles to tune human T cell functions

Nature 2023

Zi-Xian Liu (Liu Lab) Tsinghua University

Hydrolytic endonucleolytic ribozyme (HYER) is programmable for sequence-specific DNA cleavage

Science 2024

Recording: https://harvard.zoom.us/rec/share/z2e5bCkGd0uStcShHXlmGkyQpYym9_F_Xl9aXerMmlwVxhhqe9n8YIa2xpTO7my3.mUKkbQm4TkiIfls3

2024 Feb 26

Weimin Zhang, Cian Schmitt-Ulms, and Alisan Kayabolen

Date:

Monday, February 26, 2024, 1:00pm to 2:00pm

Weimin Zhang

Weimin Zhang (Boeke Lab), NYU Langone Health

Mouse genome rewriting and tailoring of three important disease loci

Nature 2023

Cian Schmitt-Ulms and Alisan Kayabolen Cian Schmitt-Ulms and Alisan Kayabolen (Abudayyeh-Gootenberg Lab), Broad Institute of MIT and Harvard

Programmable RNA writing with trans-splicing

Biorxiv 2024

Recording: https://harvard.zoom.us/rec/share/4y6ATnHkSSHM_auJ5-TKICp1REkqKDNPTP0PWCKHsEHX5qzH-HbNKV5VMTHwZssk.-gVkAwcYyFOJqbVn?startTime=1708970560000

2023 Nov 30

Symposium at Harvard Medical School (In-person & Virtual)

Date:

Thursday, November 30, 2023, 10:00am to 5:00pm

https://gess.hms.harvard.edu/symposium2023

RECORDING: https://harvard.zoom.us/rec/share/Jx744_Wu9m5RyRyeCskwpwJaKOuK-zrrXJKkfm9JZ2i7Jn_Bz2WqnduqrrYotXmw.9qWZG-F5dxlQaTk0

2023 Nov 27

BREAK

Date:

Monday, November 27, 2023, 1:00pm to 2:00pm

2023 Nov 20

Nicolas Mathis & Elijah Mena

Date:

Monday, November 20, 2023, 1:00pm to 2:00pm

nicolas

Nicolas Mathis (Schwank Lab), University of Zurich

Predicting prime editing efficiency across diverse edit types and chromatin contexts with machine learning

bioRxiv 2023

Elijah

Elijah Mena (Elledge lab), Harvard Medical School

Defining E3 ligase–substrate relationships through multiplex CRISPR screening

Nature Cell Biology 2023

2023 Nov 13

Connor Tou & Barun Mahata

Date:

Monday, November 13, 2023, 1:00pm to 2:00pm

Connor Tou and Joana Ferreira da Silva (Kleinstiver Lab), Mass General Hospital (MGH), MIT and Harvard Medical School (HMS)

Click editing enables programmable genome writing using DNA polymerases and HUH endonucleases

bioRvix 2023

barun Barun Mahata (Hilton lab), Rice University.

Compact engineered human mechanosensitive transactivation modules enable potent and versatile synthetic transcriptional control

Nature Methods 2023

Recording: https://harvard.zoom.us/rec/share/_aE2qk5exvp0PHmK_sZqH8szkq1rM_PsIPXPg_...

2023 Nov 06

BREAK

Date:

Monday, November 6, 2023, 1:00pm to 2:00pm

2023 Oct 30

Laura Breda, Tyler Papp, Michael Triebwasser and António J. Santinha

Date:

Monday, October 30, 2023, 1:00pm to 2:00pm

Brenda Triebwasser Papp Laura Breda, Tyler Papp, and Michael Triebwasser (Hamideh Parhiz Lab), Perelman School of Medicine, University of Pennsylvania, and Children's Hospital of Philadelphia

In vivo hematopoietic stem cell modification by mRNA delivery

Science 2023

Antonio Santinha (Platt Lab), ETH Zurich

Transcriptional linkage analysis with in vivo AAV-Perturb-seq

Nature 2023

Recording: https://harvard.zoom.us/rec/share/4s_CHtPkdTFGARQipXPTKvM_ecSX23Qz5MtO5q...

2023 Oct 23

Lukas Schmidheini and Chris Hsiung

Date:

Monday, October 23, 2023, 1:00pm to 2:00pm

Lukas Schmidheini (Schwank Lab), University of Zurich

Continuous directed evolution of a compact CjCas9 variant with broad PAM compatibility

Nature Chemical Biology 2023

Chris Hsiung (Gilbert Lab), Arc Institute

Higher-order combinatorial chromatin perturbations by engineered CRISPR-Cas12a for functional genomics

bioRxiv 2023

Recording: https://harvard.zoom.us/rec/share/LdKXugNIXjP5PhTv8J9Haaj66oVKXvi59DdsNQ218dE50uHrzAqvYLMdV77a8Mvw.QfP1Ob8p1iOULPER

2023 Oct 16

Dana Foss and Joseph Muldoon, and José L. McFaline-Figueroa

Date:

Monday, October 16, 2023, 1:00pm to 2:00pm

Dana Foss and Joseph Muldoon (Wilson Lab) University of California, Berkeley; (Eyquem Lab) University of California, San Francisco;

Peptide-mediated delivery of CRISPR enzymes for the efficient editing of primary human lymphocytes

Nature Biomedical Engineering 2023

José L. McFaline-Figueroa (McFaline-Figueroa Lab) Columbia University

Multiplex single-cell chemical genomics reveals the kinase dependence of the response to targeted therapy

Biorxiv 2023

Recording: https://harvard.zoom.us/rec/share/Y-lLVUkvmxe28OjlLN6BSkZcQVNfvb1eOJZFU9vuJ42gV1lbo4sQBsUX0gBckbsi.XAtEpNniDAgnAMSz?startTime=1697475727000

2023 Oct 09

HOLIDAY

Date:

Monday, October 9, 2023, 1:00pm to 2:00pm

2023 Oct 02

Goosang Yu and Martina Fiumara

Date:

Monday, October 2, 2023, 1:00pm to 2:00pm

Goosang Yu, (Hyongbum Henry Kim Lab), Yonsei University College of Medicine, Seoul 03722, Republic of Korea

Prediction of efficiencies for diverse prime editing systems in multiple cell types

Cell 2023

Martina Fiumara (Luigi Naldini Lab), San Raffaele Telethon Institute for Gene Therapy, Milan, Italy

Genotoxic effects of base and prime editing in human hematopoietic stem cells

Nature Biotechnology 2023

Recording: https://harvard.zoom.us/rec/share/Ys3BZvVH2_vyCsej3CAAGfcUsJ_CNP12vm_HHAx4nPIyMkwGvGIh_JyNHFxRhKsC.TdXN0vOe7nRpNvTh

2023 Sep 25

Stephan Riesenberg and Xiaoyi Li

Date:

Monday, September 25, 2023, 1:00pm to 2:00pm

Stephan Riesenberg, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany

Efficient high-precision homology-directed repair-dependent genome editing by HDRobust

Nature Methods 2023

Xiaoyi Li (Shendure Lab), University of Washington, Seattle, WA, USA

Chromatin context-dependent regulation and epigenetic manipulation of prime editing

bioRxiv 2023

Recording: https://harvard.zoom.us/rec/share/AW0aVbFvAK37bz67akRX3uJ33Nj_i4dD2pBD0NdspAP5hYMdSGezDJsnfjeomgLy.p3AFFhbRCaqQYdCd

2023 Sep 18

Hongyuan Fei and Xingjie Ren & Han Yang

Date:

Monday, September 18, 2023, 1:00pm to 2:00pm

Hongyuan Fei (Kevin Zhao, Qi Biodesign), (Gao Lab) University of Chinese Academy of Sciences, Beijing, China

Discovery of deaminase functions by structure-based protein clustering

Cell 2023

Xingjie Ren and Han Yang (Shen Lab); University of California, San Francisco

High throughput PRIME editing screens identify functional DNA variants in the human genome

bioRxiv 2023

RECORDING: https://harvard.zoom.us/rec/share/H-eVqKKyKCfspQByr-P34QHerPq5R9KxM5_gtCveBchjJ9qAtr1ZK_F6a-WpBaSi.wMpU6xh9tyrVrD8F

2023 May 22

George Lampe & Rebeca King and Florence Chardon

Date:

Monday, May 22, 2023, 1:00pm to 2:00pm

George Lampe & Rebeca King (Sternberg Lab). Columbia University, New York

Targeted DNA integration in human cells without double-strand breaks using CRISPR-associated transposases

Nature Biotechnology 2023

chardon Florence Chardon (Shendure Lab). University of Washington, Seattle,

Multiplex, single-cell CRISPRa screening for cell type specific regulatory elements

bioRxiv 2023

Recording: https://harvard.zoom.us/rec/share/t1DdSISXcfKagG864zFrdCEU0nXldMyd4s79aJQrH92c2-R_WR5AMknRpuom14I.dWUXrn51Yog5p7DO

2023 May 15

Break - No Seminar

Date:

Monday, May 15, 2023, 1:00pm to 2:00pm

2023 May 08

Kristin Knouse and Jaesuk Lee

Date:

Monday, May 8, 2023, 1:00pm to 2:00pm

Kristin Knouse, Massachusetts Institute of Technology (MIT).

Genome-scale CRISPR screening in a single mouse liver

Cell Genomics 2022

Jaesuk Lee (Jin-Soo Kim Lab) Center for Genome Engineering, Institute for Basic Science, Daejeon, Republic of Korea.

Prime editing with genuine Cas9 nickases minimizes unwanted indels

Nature Communications 2023

Recording: https://harvard.zoom.us/rec/share/DrnYD1LrzjDqW0v4zIQUfACZ6PCePIFKvYK1UCgiRr6mjMfInL6MVtSPhmJvU-R4.SyOXhAAuYXew4TnJ

2023 May 01

Michael Wheeler and Connor Tsuchida

Date:

Monday, May 1, 2023, 1:00pm to 2:00pm

Michael Wheeler, Brigham and Women's Hospital, Harvard Medical School, The Broad Institute

Droplet-based forward genetic screening of astrocyte–microglia cross-talk

Science 2023

Connor Tsuchida (Doudna Lab), University of California, Berkeley. Innovative Genomics Institute

Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells

bioRxiv 2023

Recording: https://harvard.zoom.us/rec/share/iSwvV_CoVdZSCIDgz_gPuiV6l0O80QPvsayOH4jNvigsNKhCqhypjouEEjXXK1xZ.k5wAD3L0gcJIp5f_

2023 Apr 24

Jing Zeng, Linda Yingqi Lin, Manuel Tognon and Qianxin Wu

Date:

Monday, April 24, 2023, 1:00pm to 2:00pm

Jing Zeng, Linda Yingqi Lin (Bauer Lab), Manuel Tognon (Giugno Lab). Boston Children's Hospital, Harvard Medical School, University Verona